Cytokine storms

Covid-19, as a virus, generally does not directly kill. Instead, it fools our own immune system into killing us via the mechanism of a cytokine storm.

It is not the only disease that can provoke cytokine storms. We don’t know how to reliably stop cytokine storms. If we did, we wouldn’t have to shut down the economy. We could just treat those who are starting to get sick so they wouldn’t develop into a cytokine storm, pay the bills, however, and we would all come out trillions of dollars ahead with a death toll of no national or international significance as the only people who would succumb would be those already on death’s door.

If nobody else will say it, I will. We don’t need to close down the majority of our economy just to change what’s written on a death certificate that was coming out anyway.

Diseases will continue to emerge. Any disease that provokes cytokine storms while not killing many itself will be just as scary as Covid-19 and we’ll be back to the question of whether we have another economic shutdown.

Cytokine storms are not just associated with infectious diseases. The first mention of the term in the literature was about graft vs host disease in a 1993 article. They entered into the general public’s imagination 15 years ago with the H5N1 flu. We don’t really understand why they happen and how to reliably stop them from taking a life. This is a public health issue deeper than how we pay for healthcare. It threatens us all and will continue to do so at irregular intervals as new diseases emerge that cause cytokine storms.

So as we move past our currently unsustainable shutdown due to Covid-19, we all have to decide whether we’re going to let cytokine storms go until the next time some disease breaks out and kills significant numbers of people via this mechanism or whether we’re going to treat this seriously so that the next time we’ll be ready. It’s our choice.

“A Fresh Perspective on the Covid-19 Numbers” – Part 2

Robert Prost follows up his previous email (posted here):

Plotted below are the covid-19 confirmed cases for Wisconsin. The data is graphed so that the first derivative plot is scaled up for better visibility. The fact that the graph has been jumping so erratically means that somebody is manipulating the data. This first derivative is the rate of change of the accumulation of new cases. That fact that it jumps around means that either someone is pushing the hospitals to change their definition of ‘confirmation’ or the virus has a mind of its own. If the changes were due to the sudden availability of additional testing, the increase should be all in one direction if additional cases were being detected. Someone is playing games in pursuit of a political agenda. Were I to hazard a guess, I’d say it is due to our addled governor, aka Tony Baloney.

Wisconsin COVID-19 Confirmed Cases

Robert concludes: “This data certainly does not give a good reason to extend the lockdown.”

SARS-CoV2/COVID-19 Update, Easter 2020 edition

There are lots of hopeful reports — despite the USA COVID-19 infections being over 1/2 million and the total deaths of over 20,000 people — that the pandemic will soon be “Over.”

This is fantasy thinking at best.   SARS-CoV2/COVID-19  won’t be over, until it is over, for YEARS.

“Over” being defined as world wide mass vaccinations to the tune of 70% of humanity or human herd immunity.   Assuming such a thing is possible, which it may not be, given this recent report from the UK Daily Mail on post SARS-CoV2/COVID-19 infection immunity —

Blow to Britain’s hopes for coronavirus antibody testing as study finds a THIRD of recovered patients have barely-detectable evidence they have had the virus already

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– Nearly third of patients have very low levels of antibodies, Chinese study found
– Antibodies not detected at all in 10 people, raising fears they could be reinfected
– Explains why UK Government repeatedly delayed rolling them out to the public

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https://www.dailymail.co.uk/news/article-8203725/Antibodies-prove-difficult-detect-Chinese-coronavirus-survivors.html

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Related studies:
Wu F et al. Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications. medRxiv 2020.03.30.20047365; doi: https://doi.org/10.1101/2020.03.30.20047365

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and

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Zhao J et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019, Clinical Infectious Diseases, , ciaa344, https://doi.org/10.1093/cid/ciaa344
total by July 1st 51,197

Or this  South Korean story on coronavirus “reactivation” —

South Korea reports recovered coronavirus patients testing positive again
APRIL 10, 2020
Josh Smith, Sangmi Cha

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https://www.reuters.com/article/us-health-coronavirus-southkorea-idUSKCN21S15X?utm_campaign=trueAnthem%3A+Trending+Content&utm_medium=trueAnthem&utm_source=facebook

The issue with most COVID-19 tests, like the ones mentioned in South Korea, is they detect SARS-CoV2 RNA. They do not detect whether the viral particles are active or not. The issue here is whether these people are shedding active viral particles that can re-infect people.    We don’t know if that is the case here from the story text.   Given how infectious it is.   This coronavirus will tell us in due course.

There are some viral diseases like Herpes that hide inside your body and reactivate to make you infectious. We do not know enough about the SARs-CoV2 virus to say whether that is the case here.

If the SARS-CoV2 virus is like Herpes in that once contracted, it never goes away and flares infectious several times a year.

And there is no herd immunity for some people no matter how often they are infected.

Then we will need multiple, cheap,   out-patient style “cure-treatments” as well as multiple vaccines, based on co-morbidities, and possibly to account for racial differences like sickle cell blood mutations, as SARS-CoV2 may well be more a blood disease than a respiratory infection in terms of it’s killing mechanism.

See:

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

There is not enough reliable data, d*mn it!

Until we get to “Over,” our old economic world of Just-In-Time, Sole Source anywhere, but especially in China, is dead without replacement.

The world is in the same position as Germany was from August 1944 – April 1945 or   Japan from August 1944 until August 1945 versus the Allied strategic bombing campaign.   We have entered the world of   End Run Production as world wide supply chains grind to a halt from various fiddly bits of intermediate parts running out without replacement.   The on-and-off hotspots world wide of COVID-19 at different times and places in the world economy is no different than WW2 strategic bombing in terms of causing random damage to the economic life support.

See also   “End Run Production” here from this one volume WW2 history book The Great Crusade:

https://books.google.com/books?id=5L-bwPZK7PQC&pg=PA420&lpg=PA420&dq=%22End+Run+Production%22&source=bl&ots=kc30FQflCj&sig=ACfU3U2kmF-kTPo0Tgr2A9_ESPKpEQAEOg&hl=en&sa=X&ved=2ahUKEwjfpurOnOPoAhUKA6wKHemwBMcQ6AEwAHoECC4QKQ#v=onepage&q=%22End%20Run%20Production%22&f=false

Be it automobiles, self propelled construction equipment, jets, power plants or the latest electronic gadget, anything that has thousands of parts sourced world wide with lots of Chinese cheap/disposable sub-component content anywhere in the supply chain simply won’t be produced for the next 18 months to three years.

This “random damage to the economic life support” effect is amplified by the unwillingness of Western private industry to invest in building the capitol equipment to produced those intermediate parts.   Because of the threat of China coming back with predatory pricing — using bought politicians to cover for them — means those parts won’t be built without massive cost plus contract government buy out of the investment risk like happened in the USA in the 1942 WW2 mobilization.

The story of   one American n95 mask manufacturer’s experience with the Obama Administration in 2009 with the Swine flu is a case in point.   The n95 mask is a 50 cent item where China pays 2 cents a mask for labor versus 10 cents a mask for American labor.   When the American manufacturer geared up to replace Chinese mask production.   China came back on-line and the Obama Administration refused to keep buying the American mask producer’s 8 cents more expensive mask when the Chinese masks were available.

Unlike almost 80 years ago, current Western and particularly American politicians are too corrupt to go too massive cost plus contract government buy out this private investment risk.   Mainly because these political elites   can’t be bothered to figure out their 10% cut.   Instead we are getting more “fiscal stimulus” AKA boondoggles that the elites will saddle the rest of us with high interest payments on huge public debts.

It will take local small to mid-sized business to get the American economy going during the COVID-19 pandemic via making products and services that don’t use the intermediate products China threatens with when the pandemic ends.

My read on what comes next economically is local/distributed production with limited capitol investment that is multi-product capable.   The name for that is additive manufacturing, AKA 3D Printing. Here are a couple of examples:

  1. The idea of 3D  Printed Sand Casting Molds For Automobile Production

voxeljet enters alliance to industrialize core tooling production using 3D printing

2. And the replacement of physical inventory with 3D printers, print media and electronic drawings:
Such “Make or buy” decisions have always been the key decision of any business.   The issue here is that middle men wholesalers and in-house warehousing holding cheap Chinese-sourced   intermediate parts are both set to go the way of the Doe-Doe Bird in a 3D/AM manufacturing dominated world.
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Distributed production in multiple localities with 3D/AM vendors for limited runs of existing intermediate products to keep production lines going.   Or the re-engineering intermediate products so one 3D/AM print replaces multiple intermediate products for the same reason, will be the stuff of future Masters of Business Administration (MBA) papers describing this imminent change over.

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But, like developing SARS-CoV2/COVID-19 vaccines, this new locally distributed manufacturing economy will take time.   The possible opening of the American economy in May 2020 will not bring the old economy of December 2019 back.

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That economy is dead.   It cannot, will not, come back.

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We will have to dance with both the sickness from SARS-CoV2/COVID-19 and the widening End Run Production product shortages that the death of the globalist   just-in-time, sole source in China economic model causes for years.

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And this is a hard reality, not a fantasy, we must all face.

America Has an Autoimmune Disease

An autoimmune disease is an illness that occurs when the body tissues are attacked by its own immune system.  The US today has this condition big-time.  Historically, the condition has arisen and reached toxic levels in other countries; as an example, France, during the run-up to the Second World War and even during the campaign of 1940.

General Edward Spears, who was Churchill’s military liaison with France, was told by Georges Mandel, the combative interior minister, about the mayor of a district in Paris which had been bombed who went about the lobbies, screaming:  I will interpellate the Government on this outrage as soon as the chamber meets!  Mandel expressed his contempt for this kind of behavior, saying sarcastically “Paris is bombed by the German?  Let’s shake our fists at or own government.”  Spears notes that “The other way, that of silently going off to collect a gun and have a shot at the enemy, was a solution that occurred only to a few…How Hitler must have laughed, I told myself.”

A few months earlier, an interviewer asked Paul Reynaud, who had just become Prime Minister of France, about his long-standing and bitter rivalry with Edouard Daladier.

Nevertheless, ”the interviewer  said, “Daladier is certainly a man who loves his country.”

“Yes,” Reynaud replied, “I believe he desires the victory of France, but he desires my defeat even more.”

This may have been a bit unfair to Daladier, who was far from the worst of the leading French politicians of the day. But it gives an accurate impression of the state of things in the late Third Republic.  And it may actually understate the state of things in America today, where for many politicians and journalists, the well-being of America and of Americans doesn’t seem to enter into the equation at all compared with the search for political advantage.

The obsession with political power, and with the denunciation of opponents, is not today limited to politicians, journalists, and ‘activists’…it has spread to a large proportion of the population.  Millions of Americans, it seems, are in a state of visceral rage against not only Trump, but against any and all of his supporters.  There is no activity, of any sort, that is safe from volcanic overflowings of political rage…not even knitting, as strange as that may seem.

It often seems impossible to find any point of entry for an attempt to get Progs to reconsider their beliefs, in however small a way.  I’m reminded of something written by Arthur Koestler, himself a former Communist, on the subject of intellectually closed systems:

A closed system has three peculiarities. Firstly, it claims to represent a truth of universal validity, capable of explaining all phenomena, and to have a cure for all that ails man. In the second place, it is a system which cannot be refuted by evidence, because all potentially damaging data are automatically processed and reinterpreted to make them fit the expected pattern. The processing is done by sophisticated methods of casuistry, centered on axioms of great emotive power, and indifferent to the rules of common logic; it is a kind of Wonderland croquet, played with mobile hoops. In the third place, it is a system which invalidates criticism by shifting the argument to the subjective motivation of the critic, and deducing his motivation from the axioms of the system itself. The orthodox Freudian school in its early stages approximated a closed system; if you argued that for such and such reasons you doubted the existence of the so-called castration complex, the Freudian’s prompt answer was that your argument betrayed an unconscious resistance indicating that you yourself have a castration complex; you were caught in a vicious circle. Similarly, if you argued with a Stalinist that to make a pact with Hitler was not a nice thing to do he would explain that your bourgeois class-consciousness made you unable to understand the dialectics of history…In short, the closed system excludes the possibility of objective argument by two related proceedings: (a) facts are deprived of their value as evidence by scholastic processing; (b) objections are invalidated by shifting the argument to the personal motive behind the objection. This procedure is legitimate according to the closed system’s rules of the game which, however absurd they seem to the outsider, have a great coherence and inner consistency.

The atmosphere inside the closed system is highly charged; it is an emotional hothouse…The trained, “closed-minded” theologian, psychoanalyst, or Marxist can at any time make mincemeat of his “open-minded” adversary and thus prove the superiority of his system to the world and to himself.

In attempting to debate with “progressives,” one often encounters this kind of closed-system thinking:  there is absolutely no way you are going to change their minds, whatever the evidence or logic.  (I don’t think this is true of  all  “progressives”otherwise the situation in America today would be even more grim than it actually isbut it’s true of a lot of them.)

But today’s Progressivism is not a coherent intellectual system with definable axioms like Marxism or a Christian theology; it seems much more a cluster of emotional reactions.

Certain Progs have gone so far out on the limb that there seems no hope they could ever come back; this certainly is true of most commentators on CNN and MSNBC…they will just become angrier and more extreme, and it will all be broadcast to millions as long as their owners (AT&T and Comcast, respectively) keep the money flowing.  But what about ordinary people, those whose lives do not center (or at least previously have not centered) around politics?…Is there any sign that some may be willing to reconsider some of their beliefs, specifically in the midst of the Cornavirus crisis?  I have seen comments by people saying they have friends who have recently been willing to reconsider their support for open borders, or for offshoring most American manufacturing to China, in the light of current events.  I haven’t seen much of this, personally.  What I see is more people who are so completely aligned with their ‘side’, that they view events largely through the light of how they can be interpreted to support that side.  These are often people who were not particularly interested in politics or political philosophy  prior to recent years.

This isn’t one of my more coherent posts, but I’d like to discuss: Can the American autoimmune disease be cured?  Why did it develop and get so bad?  What, as individuals, can we do to help with the cure or at least the mitigation?

The Far Limit

With an effort, I wrench my attention from contemplating local fall-out from the Wuhan coronavirus, or as an unknown wit called it the ‘Kung Flu’. The grocery stores we favor are pretty well picked over by mid-day, in spite of closing from 8 PM to 8AM to restock, the gym has closed, gatherings of more than ten are strongly advised against, and just about every local market or book festival that we had considered participating in has been cancelled or postponed until summer or even later when, presumably, either the medical wizards will have a handle on the Kung Flu, or people will stop panicking over it.

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