Science

“A Fresh Perspective on the Covid-19 Numbers” – Part 2

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Robert Prost follows up his previous email (posted here):

Plotted below are the covid-19 confirmed cases for Wisconsin. The data is graphed so that the first derivative plot is scaled up for better visibility. The fact that the graph has been jumping so erratically means that somebody is manipulating the data. This first derivative is the rate of change of the accumulation of new cases. That fact that it jumps around means that either someone is pushing the hospitals to change their definition of ‘confirmation’ or the virus has a mind of its own. If the changes were due to the sudden availability of additional testing, the increase should be all in one direction if additional cases were being detected. Someone is playing games in pursuit of a political agenda. Were I to hazard a guess, I’d say it is due to our addled governor, aka Tony Baloney.

Wisconsin COVID-19 Confirmed Cases

Robert concludes: “This data certainly does not give a good reason to extend the lockdown.”

SARS-CoV2/COVID-19 Update, Easter 2020 edition

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There are lots of hopeful reports — despite the USA COVID-19 infections being over 1/2 million and the total deaths of over 20,000 people — that the pandemic will soon be “Over.”

This is fantasy thinking at best.  SARS-CoV2/COVID-19 won’t be over, until it is over, for YEARS.

“Over” being defined as world wide mass vaccinations to the tune of 70% of humanity or human herd immunity.  Assuming such a thing is possible, which it may not be, given this recent report from the UK Daily Mail on post SARS-CoV2/COVID-19 infection immunity —

Blow to Britain’s hopes for coronavirus antibody testing as study finds a THIRD of recovered patients have barely-detectable evidence they have had the virus already

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– Nearly third of patients have very low levels of antibodies, Chinese study found
– Antibodies not detected at all in 10 people, raising fears they could be reinfected
– Explains why UK Government repeatedly delayed rolling them out to the public

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https://www.dailymail.co.uk/news/article-8203725/Antibodies-prove-difficult-detect-Chinese-coronavirus-survivors.html

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Related studies:
Wu F et al. Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications. medRxiv 2020.03.30.20047365; doi: https://doi.org/10.1101/2020.03.30.20047365

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and

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Zhao J et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019, Clinical Infectious Diseases, , ciaa344, https://doi.org/10.1093/cid/ciaa344
total by July 1st 51,197

Or this South Korean story on coronavirus “reactivation” —

South Korea reports recovered coronavirus patients testing positive again
APRIL 10, 2020
Josh Smith, Sangmi Cha

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https://www.reuters.com/article/us-health-coronavirus-southkorea-idUSKCN21S15X?utm_campaign=trueAnthem%3A+Trending+Content&utm_medium=trueAnthem&utm_source=facebook

The issue with most COVID-19 tests, like the ones mentioned in South Korea, is they detect SARS-CoV2 RNA. They do not detect whether the viral particles are active or not. The issue here is whether these people are shedding active viral particles that can re-infect people.  We don’t know if that is the case here from the story text.  Given how infectious it is.  This coronavirus will tell us in due course.

There are some viral diseases like Herpes that hide inside your body and reactivate to make you infectious. We do not know enough about the SARs-CoV2 virus to say whether that is the case here.

If the SARS-CoV2 virus is like Herpes in that once contracted, it never goes away and flares infectious several times a year.

And there is no herd immunity for some people no matter how often they are infected.

Then we will need multiple, cheap,  out-patient style “cure-treatments” as well as multiple vaccines, based on co-morbidities, and possibly to account for racial differences like sickle cell blood mutations, as SARS-CoV2 may well be more a blood disease than a respiratory infection in terms of it’s killing mechanism.

See:

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism

https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

There is not enough reliable data, d*mn it!

Until we get to “Over,” our old economic world of Just-In-Time, Sole Source anywhere, but especially in China, is dead without replacement.

The world is in the same position as Germany was from August 1944 – April 1945 or  Japan from August 1944 until August 1945 versus the Allied strategic bombing campaign.  We have entered the world of  “End Run Production“ as world wide supply chains grind to a halt from various fiddly bits of intermediate parts running out without replacement.  The on-and-off hotspots world wide of COVID-19 at different times and places in the world economy is no different than WW2 strategic bombing in terms of causing random damage to the economic life support.

See also  “End Run Production” here from this one volume WW2 history book The Great Crusade:

https://books.google.com/books?id=5L-bwPZK7PQC&pg=PA420&lpg=PA420&dq=%22End+Run+Production%22&source=bl&ots=kc30FQflCj&sig=ACfU3U2kmF-kTPo0Tgr2A9_ESPKpEQAEOg&hl=en&sa=X&ved=2ahUKEwjfpurOnOPoAhUKA6wKHemwBMcQ6AEwAHoECC4QKQ#v=onepage&q=%22End%20Run%20Production%22&f=false

Be it automobiles, self propelled construction equipment, jets, power plants or the latest electronic gadget, anything that has thousands of parts sourced world wide with lots of Chinese cheap/disposable sub-component content anywhere in the supply chain simply won’t be produced for the next 18 months to three years.

This “random damage to the economic life support” effect is amplified by the unwillingness of Western private industry to invest in building the capitol equipment to produced those intermediate parts.  Because of the threat of China coming back with predatory pricing — using bought politicians to cover for them — means those parts won’t be built without massive cost plus contract government buy out of the investment risk like happened in the USA in the 1942 WW2 mobilization.

The story of  one American n95 mask manufacturer’s experience with the Obama Administration in 2009 with the Swine flu is a case in point.  The n95 mask is a 50 cent item where China pays 2 cents a mask for labor versus 10 cents a mask for American labor.  When the American manufacturer geared up to replace Chinese mask production.  China came back on-line and the Obama Administration refused to keep buying the American mask producer’s 8 cents more expensive mask when the Chinese masks were available.

Unlike almost 80 years ago, current Western and particularly American politicians are too corrupt to go too massive cost plus contract government buy out this private investment risk.  Mainly because these political elites  can’t be bothered to figure out their 10% cut.  Instead we are getting more “fiscal stimulus” AKA boondoggles that the elites will saddle the rest of us with high interest payments on huge public debts.

It will take local small to mid-sized business to get the American economy going during the COVID-19 pandemic via making products and services that don’t use the intermediate products China threatens with when the pandemic ends.

My read on what comes next economically is local/distributed production with limited capitol investment that is multi-product capable.  The name for that is additive manufacturing, AKA 3D Printing. Here are a couple of examples:

  1. The idea of 3D Printed Sand Casting Molds For Automobile Production

voxeljet enters alliance to industrialize core tooling production using 3D printing

2. And the replacement of physical inventory with 3D printers, print media and electronic drawings:
Such “Make or buy” decisions have always been the key decision of any business.  The issue here is that middle men wholesalers and in-house warehousing holding cheap Chinese-sourced  intermediate parts are both set to go the way of the Doe-Doe Bird in a 3D/AM manufacturing dominated world.
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Distributed production in multiple localities with 3D/AM vendors for limited runs of existing intermediate products to keep production lines going.  Or the re-engineering intermediate products so one 3D/AM print replaces multiple intermediate products for the same reason, will be the stuff of future Masters of Business Administration (MBA) papers describing this imminent change over.

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But, like developing SARS-CoV2/COVID-19 vaccines, this new locally distributed manufacturing economy will take time.  The possible opening of the American economy in May 2020 will not bring the old economy of December 2019 back.

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That economy is dead.  It cannot, will not, come back.

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We will have to dance with both the sickness from SARS-CoV2/COVID-19 and the widening “End Run Production“ product shortages that the death of the globalist  just-in-time, sole source in China economic model causes for years.

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And this is a hard reality, not a fantasy, we must all face.

“A Fresh Perspective on the Covid-19 Numbers”

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Robert Prost emails:

I wanted to share with you, my take on the corona virus situation in the United States.
 
But first, a brief introduction. I am professor emeritus at the Medical College of Wisconsin in Milwaukee.
 
I have a PhD in Biophysics and spent my career in MRI-based research, mostly on brain tumors.
 
I check the Johns Hopkins’ website every day for the progress of the epidemic and I had a feeling about the numbers I’ve been seeing.
 
The website: https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 is very good.
 
The daily case number totals can be extracted by mousing over each plotted point in the graph in the lower right hand corner of the screen.
 
The curve at first looks daunting, it seems to be shooting straight up. But being at least in part a mathematician, I wondered about the velocity of this upward move in cases.
 
If the velocity was going up, the epidemic would be accelerating, the epidemic would be worsening. If going down, it would be getting better (slowing).
 
So I plotted the data and took the first derivative with respect to time. What it shows is that the velocity of the epidemic in the US is definitely slowing, and quickly.
 
While the number of confirmed cases continues to rise, it is rising more slowly. If there were a confounding effect from increased surveillance (more testing revealing yet more cases), the apparent velocity should be going up.
 
Instead, it is going down. So I believe the effect to be real, and thus I believe we are witnessing the beginning of the end of the epidemic. While this data says nothing about the potential for re-emergence in the fall or following spring, it does suggest that we have in fact, flattened the curve.

US Covid-19 Cases and Rate of Change

UPDATE: A follow-up email from Robert is posted here.

Retrotech — With a Future?

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Before there were electronic digital computers, there were mechanical analog computers. Although now obsolete for practical computation, these devices might actually have an useful future ahead of them–in education.

Mechanical analog computation (analog means that calculation is done by measuring rather than by counting) goes back to the Greek Antikythera mechanism (65 BC), which was used to predict the positions of heavenly bodies. The modern era of analog computing began with the work done by James Thompson and his brother William (Lord Kelvin) in the 1870s. First, James Thompson created a mechanical device that performs the calculus function of integration.

Lord Kelvin applied this device…along with other mechanisms for addition and trigonometric functions…to create a mechanical tide-prediction system. These tide predictors had a pretty good run: the invention was announced in 1876, and some of these systems were still in use in the early 1970s!

For those who haven’t studied calculus, integration can be thought of as a kind of continuous addition.  Imagine a hose with a fluctuating flow rate filling a pool: by integrating the rate of flow, you can calculate the volume of water added to the pool.

The basic concept of a mechanical integrator is shown below.

mechanical-integrator-modified

If the vertical shaft is turned at a constant rate, and the small wheel is moved in and out according to the changing value of some some variable Y, then the rotation of the horizontal shaft Z will represent the integral of Y with respect to time.  If Y is the rate of flow of the a hose, Z will be the total volume  added to the pool. If Y represents the acceleration of a vehicle, then the output shaft will give that vehicle’s speed at any moment.  Connect the output to the input of another integrator, and you will get the distance traveled.

Vannevar Bush, who would become Roosevelt’s science adviser during WWII, combined the integrator and other computing mechanisms to create a highly general mechanical computer, called a differential analyzer. Completed in 1931, it was not restricted to a single application, but could be programmed–with a wrench and screwdriver to alter the connections–for a wide range of problems. Complex chains of calculation were possible, including the ability for a result at one stage to be fed back as input at an earlier stage–for example, the speed of a simulated vehicle affects its air resistance, which in turn influences its acceleration…which integrates back to its speed.

Other differential analyzers were built in the U.S.,  Norway, and Britain, and were used for applications including heat-flow analysis, electrical network stability analysis, soil-erosion studies, artillery firing table preparation, and studies of the loading and deflection of beams. It is rumored that a British analyzer was used in the planning for the bouncing-bomb attack on German hydroelectric dams during WWII. Differential analyzers appeared in several movies, including the 1951 film When Worlds Collide  (video clip). The ultimate in mechanical analog computation was the Rockefeller Differential Analyzer, a rather baroque (and very expensive) machine built in 1942. It was decommissioned in 1954, on the belief that the future of calculation would belong to the electronic computer, and especially the electronic digital computer.   Following the decommissioning, the mathematician Warren Weaver wrote:

It seems rather a pity not to have around such a place as MIT a really impressive Analogue computer; for there is vividness and directness of meaning of the electrical and mechanical processes involved… which can hardly fail, I would think, to have a very considerable educational value. A Digital Electronic computer is bound to be a somewhat abstract affair, in which the actual computational processes are fairly deeply submerged.

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So, Really Want to Talk About Foreign Intervention? (updated)

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Much ink and many photons have been spent discussing Russia’s attempts to influence (or at least disrupt) the American 2016 Presidential campaign.  Meanwhile…

Daryl Morey, general manager of the Houston Rockets, sent out a tweet which said “Fight for Freedom, Stand with Hong Kong.”  Tencent, the NBA’s exclusive digital partner in China, reacted by suspending business relations with the Rockets, and is offering fans who purchased a year-long pass to watch Rockets games the chance to switch it to a different team. A number of other Chinese companies have pulled sponsorship deals with the Rockets as well.  Morey issued an apology which said in part ” was merely voicing one thought, based on one interpretation, of one complicated event. I have had a lot of opportunity since that tweet to hear and consider other perspectives.”

And from last year:  here’s an appalling story about how anger from the Chinese government led Marriott Corporation to fire an employee who had ‘liked’ a tweet which congratulated the company for listing Tibet as a country, along with Hong Kong and Taiwan….of course, the Chinese regime considers Tibet to be a part of China, not a separate country.

China forced Marriott to suspend all online booking for a week at its nearly 300 Chinese hotels. A Chinese leader also demanded the company publicly apologize and “seriously deal with the people responsible,” the Journal reported.

And boy, did Marriott ever apologize. Craig Smith, president of the hotel chain’s Asian division, told the China Daily that Marriott had committed two significant mistakes — presumably the survey listing Tibet and the liked tweet — that “appeared to undermine Marriott’s long-held respect for China’s sovereignty and territorial integrity.”

He announced an “eight-point rectification plan” that included education for hotel employees across the globe and stricter supervision.

And the Marriott executive said this to China’s most-read English-language newspaper: “This is a huge mistake, probably one of the biggest in my career.”

(More here…according to this article, the Chinese suppression of Marriott bookings was in response to the initial listing of Tibet as a country rather than to the tweet approving of this listing)

The Chinese economy is, shall we say, a little more dynamic than that of Russia, so the government of China has much more ability to strong-arm American corporations (in general) than does the Putin regime.

Turning now from the hotel industry to the movie industry, Richard Gere says that Chinese pressure due to his stand on Tibetan independence has led to his being dropped from big Hollywood movies.  Also:

Gere’s activities have not just made Hollywood apparently reluctant to cast him in big films, he says they once resulted in him being banished from an independently financed, non-studio film which was not even intended for a Chinese release.

“There was something I was going to do with a Chinese director, and two weeks before we were going to shoot, he called saying, ‘Sorry, I can’t do it,’” Gere recalled. “We had a secret phone call on a protected line. If I had worked with this director, he, his family would never have been allowed to leave the country ever again, and he would never work.”

See also How China’s Censors Influence Hollywood.  Because the Chinese market is so large…(Fast and Furious 7 pulled in $388 million in China, more than it made in the US)…the influence of the Chinese regime on US film production and distribution has become immense.

In recent years, foreign filmmakers have also gone out of their way not to provoke the Communist Party. For instance, the 2012 remake of the Cold War action movie, Red Dawn, originally featured Chinese soldiers invading an American town. After filming was complete, though, the moviemakers went back and turned the attacking army into North Koreans, which seemed a safer target, at least until last year’s hack of Sony Pictures.

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Ying Zhu, a professor of media culture at the College of Staten Island at the City University of New York, worries China’s growing market power is giving the Communist Party too much leverage over Hollywood.

“The Chinese censors can act as world film police on how China can be depicted, how China’s government can be depicted, in Hollywood films,” she says. “Therefore, films critical of the Chinese government will be absolutely taboo.”

In the late 1990s, when China’s box office was still small, Hollywood did make movies that angered the Communist Party, such as Seven Years In Tibet, about the life of the Dalai Lama, and Red Corner, a Richard Gere thriller that criticized China’s legal system. Given the importance of the China market now, Zhu says those movies wouldn’t get financing today.

Plus, Chinese companies have snapped up Hollywood studios, theaters and production companies.

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