Science

The Internet Archive

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I am bit surprised the the Internet Archive isn’t much more well-known.

From their mission statement:

The Internet Archive is a 501(c)(3) non-profit that was founded to build an Internet library. Its purposes include offering permanent access for researchers, historians, scholars, people with disabilities, and the general public to historical collections that exist in digital format. Founded in 1996 and located in San Francisco, the Archive has been receiving data donations from Alexa Internet and others. In late 1999, the organization started to grow to include more well-rounded collections. Now the Internet Archive includes texts, audio, moving images, and software as well as archived web pages in our collections, and provides specialized services for adaptive reading and information access for the blind and other persons with disabilities.

Just follow the links in the quote above and you’ll find an incredible amount of each of the mentioned media.

“Watchful Waiting” vs. “Precautionary Principle”

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Watchful Waiting = Do nothing, even though it may be a good idea to do something, because it’s difficult to justify doing something when institutional third-party payers who evaluate everything in terms of population average costs and benefits rather than your cost and your benefit are making the decisions.

Precautionary Principle = Take extreme measures, even though it may be a good idea to do nothing, because it’s difficult to justify doing nothing when activists who evaluate everything in terms of hypothetical worst cases rather than probability weighted costs and benefits are making the decisions.

The question that always matters most is “Who decides?”. Answer it and you can usually predict what the answers to the other questions will be.

Preserve Yourself With Preservatives

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Noting the passage of the creator of the Doritos chip who recently died at the ripe old age of 97, Glenn Reynolds quips, “I think the preservatives in junk food keep you young.”

Actually, there is reason to suspect that he might be right.

One of the most common preservatives is butylated hydroxyanisole also know has BHA or E320 in food labeling. BHA keeps foods from growing rancid by preventing the oxidation of fats by oxygen free radicals.

Say, what do you call a substances that controls oxygen free radicals? It’s right on the tip of my tongue…

… Oh, right, an anti-oxidant! You know, those things every other organic food product is advertised as having.

Benzoic acid, probably most commonly seen as Sodium Benzoate (E211) is another common bugaboo. In fact, its probably the poster child preservative being one whose name most people will recognize.

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A New Doctrine?

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Carter Doctrine:”The Carter Doctrine was a policy proclaimed by President of the United States Jimmy Carter in his State of the Union Address on January 23, 1980, which stated that the United States would use military force if necessary to defend its national interests in the Persian Gulf region. The doctrine was a response to the 1979 invasion of Afghanistan by the Soviet Union, and was intended to deter the Soviet Union—the Cold War adversary of the United States—from seeking hegemony in the Gulf. After stating that Soviet troops in Afghanistan posed “a grave threat to the free movement of Middle East oil,” Carter proclaimed:….”

On the tenth anniversary of 9/11, as we remember the fallen and the many members of the armed services of the United States who have served for ten years of war, heroically, at great sacrifice and seldom with complaint, we also need to recall that we should not move through history as sleepwalkers. We owe it to our veterans and to ourselves not to continue to blindly walk the path of the trajectory of 9/11, but to pause and reflect on what changes in the last ten years have been for the good and which require reassessment. Or repeal. To reassert ourselves, as Americans, as masters of our own destiny rather than reacting blindly to events while carelessly ceding more and more control over our lives and our livelihoods to the whims of others and a theatric quest for perfect security. America needs to regain the initiative, remember our strengths and do a much better job of minding the store at home.

– Zenpundit, The Nine-Eleven Century

1. Canada and oil sands: “Bituminous sands, colloquially known as oil sands or tar sands, are a type of unconventional petroleum deposit. The sands contain naturally occurring mixtures of sand, clay, water, and a dense and extremely viscous form of petroleum technically referred to as bitumen (or colloquially “tar” due to its similar appearance, odour, and colour). Oil sands are found in large amounts in many countries throughout the world, but are found in extremely large quantities in Canada and Venezuela.[1]”

2. Israel and Natural Gas: “In recent years, Israel has found and begun developing massive natural gas deposits in the Mediterranean Sea. There is much more wealth underwater– the U.S. Geological Survey estimates that the Levant Basin contains as much as 122 trillion cubic meters of recoverable gas — and all countries around the basin want a piece of the action.”

3. Russian state oil and American oil companies: “America’s largest oil company last week reached an historic agreement with Russia’s state oil company, Rosneft. ExxonMobil now will take the place of BP (British Petroleum), whose dealings with Rosneft collapsed earlier this year.”

4. Dakotas and oil reserves: “America is sitting on top of a super massive 200 billion barrel Oil Field that could potentially make America Energy Independent and until now has largely gone unnoticed. Thanks to new technology the Bakken Formation in North Dakota could boost America’s Oil reserves by an incredible 10 times, giving western economies the trump card against OPEC’s short squeeze on oil supply and making Iranian and Venezuelan threats of disrupted supply irrelevant.”

5. Bloom boxes: “One example to illustrate why the future is proving elusive in the USA: There is a stand-alone electricity providing unit called the Bloom Energy Server or “Bloom Box” — small, simple to use — which can power any home or commercial building. The wondrous box has already been test-driven; Google, eBay and a number of other Fortune 500 companies have a few Bloom Boxes and they’re saving fortunes in electrical bills.

In other words, the Bloom Box can make America’s electricity grid obsolete. There are only two things holding the box back from being installed in every residential, commercial and government space in the USA:

a) Bloom Energy, the company that makes the box, doesn’t have large manufacturing capacity.

b) The U.S. energy industry doesn’t want to be shoved around by a box. (The same for much of the ‘Green Jobs’ sector that the federal government has been pushing hard. The Bloom Box technology makes windmill and solar panel technologies obsolete.”

The GOP debates have been intellectually vapid and the fault does not lie entirely with our lightweight media moderators. Ladies and gentlemen, you are “auditioning” for the toughest job in the world. Ladies and gentlemen, you are genuinely interesting and accomplished people. Be leaders. Hire some decent speech coaches, do a little background wonky reading and show us your vision for the future.

Update: I made a few edits for clarity. Thanks for the comments, everyone. I don’t know squat about this topic. Carl from Chicago is definitely the “go to” guy on energy topics around here but I’ve been bored with the debates and wanted to blog about that for some time now. Also, I don’t know what the whole “ladies and gentlemen” thing is about. It’s kinda affected. Incorrect, too. Only one lady has been involved in the formal debates….so far….

Does this sound familiar ?

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The science community is now closing in on an example of scientific fraud at Duke University. The story sounds awfully familiar.

ANIL POTTI, Joseph Nevins and their colleagues at Duke University in Durham, North Carolina, garnered widespread attention in 2006. They reported in the New England Journal of Medicine that they could predict the course of a patient’s lung cancer using devices called expression arrays, which log the activity patterns of thousands of genes in a sample of tissue as a colourful picture. A few months later, they wrote in Nature Medicine that they had developed a similar technique which used gene expression in laboratory cultures of cancer cells, known as cell lines, to predict which chemotherapy would be most effective for an individual patient suffering from lung, breast or ovarian cancer.
 
At the time, this work looked like a tremendous advance for personalised medicine—the idea that understanding the molecular specifics of an individual’s illness will lead to a tailored treatment.

This would be an incredible step forward in chemotherapy. Sensitivity to anti-tumor drugs is the holy grail of chemotherapy.

Unbeknown to most people in the field, however, within a few weeks of the publication of the Nature Medicine paper a group of biostatisticians at the MD Anderson Cancer Centre in Houston, led by Keith Baggerly and Kevin Coombes, had begun to find serious flaws in the work.
 
Dr Baggerly and Dr Coombes had been trying to reproduce Dr Potti’s results at the request of clinical researchers at the Anderson centre who wished to use the new technique. When they first encountered problems, they followed normal procedures by asking Dr Potti, who had been in charge of the day-to-day research, and Dr Nevins, who was Dr Potti’s supervisor, for the raw data on which the published analysis was based—and also for further details about the team’s methods, so that they could try to replicate the original findings.

The raw data is always the place that any analysis of another’s work must begin.

Dr Potti and Dr Nevins answered the queries and publicly corrected several errors, but Dr Baggerly and Dr Coombes still found the methods’ predictions were little better than chance. Furthermore, the list of problems they uncovered continued to grow. For example, they saw that in one of their papers Dr Potti and his colleagues had mislabelled the cell lines they used to derive their chemotherapy prediction model, describing those that were sensitive as resistant, and vice versa. This meant that even if the predictive method the team at Duke were describing did work, which Dr Baggerly and Dr Coombes now seriously doubted, patients whose doctors relied on this paper would end up being given a drug they were less likely to benefit from instead of more likely.

In other words, the raw data was a mess. The results had to be random.

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