Science

Consumer Question – 23andme

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The musings on the random and tragic nature of life remind us of how little we know – and control. But it reminded me of the marketing of a step toward more control: how good are the DNA products? My daughter’s friend, visiting for Thanksgiving, sent her spit to 23andme. The results included a genetic tendency toward weight-related diseases, which led her to a diet and gym membership. Not surprisingly, it linked her with her mother, but also with a cousin neither she nor her mother knew existed. They met, looked each other over, compared notes: they were cousins.

Anyway, she sat in our living room flipping through her smart phone (it gives monthly updates); she was vulnerable to diabetes but less so to Parkinson’s. Genetic weaknesses are becoming obvious as we near retirement; unfortunately, we learn our vulnerabilities at every office visit.

Still, has anyone done this or similar ones? How accurate, how useful, and how much does this (or do others) add to the cloud-knowledge of genes & disease? (Other friends used a different site, but learned what human history would say – that they were both from England and before that Africa.)

Of course, whether it is worth the money or not, whether it is accurate or not, ignores the big question: does such knowledge lead us to believe we have an autonomy still not – never will be – ours? Will knowing more of “who we are” mislead or arm us?

Seventy

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“On the afternoon of December 2, 1942, the Atomic Age began inside an enormous tent on a squash court under the stands of the University of Chicago’s Stagg Field. There, headed by Italian scientist Enrico Fermi, the first controlled nuclear fission chain reaction was engineered. The result—sustainable nuclear energy—led to creation of the atomic bomb and nuclear power plants—two of the twentieth century’s most powerful and controversial achievements.”

I was there halfway between then and now. I am a by-product of the Manhattan Project, being the son of a onetime rifleman in an infantry platoon who was on a troopship in the Pacific on August 6, 1945, in transit for Operation Downfall. He went to the Philippines instead, and never heard a shot fired in anger. I did not matriculate at Chicago to repay a debt which is fortunate, because as things went, the University spent a good deal of money on me for (so far) no return whatsoever.

Earlier today I went to a lecture, “Talking Tolkien: War and J.R.R. Tolkien,” in the appropriately subterranean research center of the National World War I Museum at Liberty Memorial. It was given by Janet Brennan Croft of the University of Oklahoma, who has a book out that I suppose I will buy, to add to the same shelf containing the Hobbit, the trilogy, the Silmarillion, the Letters, and Tolkien and the Great War (all of which were referenced at some point in her talk).

I didn’t hear all that much that was new, but I didn’t expect to. It was well worth going, however; I suppose the biggest “delta” was about how his writing changed after he had children and especially when two of them served in the military in WWII. She also pointed out that all the heroic leaders in the trilogy lead from the front, while the villainous leaders are far in the rear, the equivalent of the “chateau generals.”

Another insight was how much the “black breath” and Frodo’s melancholia resemble PTSD. In combination with her remarks about parent-child relationships, this caused me to ask a question about what turns out to be Letter #74, written to Stanley Unwin on 29 June 1944, which includes the sentence: “I have at the moment another son, a much damaged soldier, at Trinity trying to do some work and recover a shadow of his old health.” a reference to his son Michael, who was pretty severely PTSD’d for a while. So out of slightly morbid curiosity, I asked if she knew anything more about that episode. She did not but said that there are probably more letters, unpublished, that would have details, and perhaps they will eventually see the light of day.

Scripture reading in church this morning was Isaiah 2:1-5. Verse 4 is of course poignant in light of today’s anniversary. If we really are entering the Crisis of 2020, those swords won’t be beaten into plowshares any time soon. Indeed, some future analog of December 2nd, 1942, presumably involving nanomachinery rather than tons of graphite blocks and lumps of enriched uranium, will happen in a laboratory somewhere in the world in another decade or so.

Far out there

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Once again, Craig Venter is looking for new challenges. The latest may be Martian DNA.

I have thought for some time that life on Mars is going to consist of microorganisms and be buried several feet below the surface of the planet soil. I have even blogged about it before.

Now, there is a possibility of a nucleotide sequencer that could go to Mars on the next probe in 2018.

In what could become a race for the first extraterrestrial genome, researcher J. Craig Venter said Tuesday that his Maryland academic institute and his company, Synthetic Genomics, would develop a machine capable of sequencing and beaming back DNA data from the planet.

Separately, Jonathan Rothberg, founder of Ion Torrent, a DNA sequencing company, is collaborating on an effort to equip his company’s “Personal Genome Machine” for a similar task.

“We want to make sure an Ion Torrent goes to Mars,” Rothberg told Technology Review.

Although neither team yet has a berth on a Mars rocket, their plans reflect the belief that the simplest way to prove there is life on Mars is to send a DNA sequencing machine.

“There will be DNA life forms there,” Venter predicted Tuesday in New York, where he was speaking at the Wired Health Conference.

Venter said researchers working with him have already begun tests at a Mars-like site in the Mojave Desert. Their goal, he said, is to demonstrate a machine capable of autonomously isolating microbes from soil, sequencing their DNA, and then transmitting the information to a remote computer, as would be required on an unmanned Mars mission. Heather Kowalski, a spokeswoman for Venter, confirmed the existence of the project but said the prototype system was “not yet 100 percent robotic.”

Doing this on Mars would avoid the problem of contamination by earth organisms. New life forms that don’t use DNA might be a problem but most people who have thought about this believe that DNA is the genetic material of all life forms. Of course, protein, which may have been the original genetic material on earth could also be the Martian equivalent.

We are starting to see commercial spacecraft develop and one was used to reach the international space station recently. A Mars mission is another order of complexity but by 2018, it may be an option.

RuiNation

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So a little over six weeks to go until Election Day; I guess we can call this the final heat. Texas is pretty much a red state stronghold, although there are pockets of blue adherents throughout. Yes, even in my neighborhood, there are a handful of defiant Obama-Biden yard signs visible, although outnumbered at least two to one by Romney-Ryan signs. It amounts to about a dozen, all told; I think that most of my neighbors prefer keeping their political preferences this time around strictly to themselves.

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I’m More Awesome Than You CAN Imagine

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Sorry I haven’t been blogging any during the last eight months but the truth is that I’ve been wrestling with a big decision that affects everyone and I didn’t quite know how to explain it. Now, I’ve come to a decision and I think it only right that I inform you all of it so that you have some time to prepare yourself.

Here goes… I’m turning off the Universe.

Yep, that’s right, the whole shebang, from littlest Higgs Boson to the greatest galaxy clusters. Say goodnight, Gracie.

I know this will be hard to accept, but, you see, you’re not real. I mean, you are real as far as the experience of yourself and every other human being you know of but you aren’t, you know, real real.

I’m not explaining this very well.

You see, I wrote you. That is to say I programmed you.   I programmed you and every other person, place and thing in your universe. You’re  just a simulation, a very big video game,  based loosely on once-real people, places and things that I created. Not only did I create the simulation but I can start it, stop it, rewind it and alter it at will.

And all that kinda makes me god. I mean not GOD god but just god of the universe you experience. Let’s just say, “god as far as you are concerned.”

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